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Hyperextensibility in Ehlers–Danlos syndrome Bruises in Ehlers–Danlos syndrome Ehlers-Danlos syndrome Ehlers-Danlos syndrome Other forms of EDS may show: Periodontal involvement Severe and intractable inflammation of the gum Lack of attached gum Skin Thin and translucent skin with visible underlying blood vessels and varicose veins Prematurely aged appearance of thin wrinkled skin particularly on hands and feet (acrogeria in vascular EDS) Epicanthic folds make the bridge of the nose appear wide Pretibial plaques Elastosis perforans serpiginosa A long philtrum and thin lips Lobeless ears Insensitivity to local anaesthetics

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SF can be highly effective in the preservation of the integrity and function of the blood–brain barrier (BBB), to which it is permeable